Síntesis diastereoselectiva del ((R)-2-((1-Etoxi-1-Oxo-4-Fenilbutan-2-Ildeno) Amino)-3-(1H-Imidazol-5-IL)Propanoil)-L-Prolina como un inhibidor de la enzima convertidora de angiotensina (IECA) derivado análogo del enalapril

Abstract

A diastereoselective synthesis of the drug ((R) -2 - ((1-ethoxy-1-oxo-4-phenylbutan-2-yldene) amino) -3- (1 H -imidazol-5-yl) propanoyl) -L -prolina which happened in two stages. In the first stage the compound (2R) -1 - [(2S) -2-amino-3- (1 H -imidazol-5-yl) propanoyl] pyrrolidine-2-carboxylic acid was obtained in a yield of 83.49% With a molecular weight of 252,270 g / mol, this compound was a precursor to the second stage in which a yield of 72.27% with a molecular mass of 440.49 g / mol was obtained. For both compounds, IR and H-NMR tests were performed in which the expected functional groups and in turn the various displacement of the gates were evidenced, thus characterizing the drug.