Estudio de la reactividad racémica y enantioselectiva del benzoilnitrometano frente a enales.

Abstract

The strategies of chemical synthesis have taken great value when results allow to obtain compounds with a high biological interest. These molecules with higher biological activity are chiral, enantiomers or diastereoisomers. In principle, obtencion of chiral compounds came entirely from natural sources that after a series of chemical transformations a unique compound of interest is obtained. But this methodology had several difficulties, it leds to rise of new synthetic methods and the beginning of asymmetric catalysis which is based on three pillars: biocatalysis, metal-catalysis and organocatalysis. The interest of the biological potencial of some enantiomeric compounds had origin since the case of thalidomide in fifties, where this drug was given in racemic mix to pregnant women for the treatment nausea. however years later, studies reveled that only one enantiomer relieved nausea (R-thalidomide), while the other enantiomer (S-thalidomide) produced teratogenic malformations. This leads to the importance of the characterization and identification of different chiral molecules.