Andamios tisulares de PLA, métodos de construcción y propiedades mecánicas (Revisión)

Abstract

This article presents a systematic review of scientific articles related to polylactic acid (PLA) tissue scaffolds used in tissue repair and regenerative treatments. PLA is presented as a great alternative for its use in this technology due to its high biocompatibility with the human body and the approval for clinical uses by the FDA. Topics such as the manufacture of PLA, construction by means of 3D printing, electrospinning, and the importance of surface treatments to improve the topography of the scaffold are reviewed, compiling information such as the catalysts used for the manufacture of PLA, design variables such as temperatures, flow rates, distances and applied voltages. It is evident that the mechanical, physical, chemical and biological properties directly influence the functionality of the scaffold such as hydrophobicity, cell adhesion, cytotoxicity, biodegradation, cell elimination and low immune response. The tissue scaffolds presented in this review showed the advances in the construction of tissue scaffolds with PLA, the good support conditions they present for generating adequate cell communication, and the low toxicity presented in their installation in vivo and in animal tissue.