Estudio del Comportamiento Biofísico de Películas Interfaciales de Surfactante Pulmonar Sometidas a Ciclos de Compresión Expansión.

Abstract

It has been very important the interdisciplinary study of interfacial phenomena, such as the biophysical study and analysis of interfacial films of pulmonary surfactant (SP). This substance is a surfactant, which is important for breathing. The absence of lung surfactant in infants is clinically known as Infant Respiratory Distress Syndrome (SDRI). This affection is the major cause of death for premature babies because their lung have to do more work to keep the respiratory balance. Treatment of this disease is given by the administration of exogenous surfactant preparations from animal origin or mixtures with artificial supplements. Therefore it is very important the study and analysis of the behavior of films of lung surfactant through the balance of Langmuir, which allows an approach in vitro study of the biophysical features of interfacial activity of films pulmonary surfactant under compression-expansion processes. This analysis allows a support to the hypothesis that a lower mass of SP (10 ug), higher energy cost is required because the need for a higher percentage of compression of the interfacial film, since it does not reach pressure values surface close to 72 mN / m, being the pressure value achieved of ± 45 mN / m for a work interfacial 22,4x 〖10〗 ^ (- 6) J and a compression ratio of 90%.