Síntesis de complejos bidentados salicilimina – Níquel (II) y su aplicación en síntesis orgánica

Abstract

This work proposes the generation of nickel catalysts that promote new reactions through organometallic processes, leading to obtaining value-added products of high interest for organic synthesis. Salicylaldehyde as a precursor in activities of catalytic synthesis of Nickel (II) complexes and its two active functional groups allow Salicylaldehyde and its isomers or derivatives to be related to primary amines, this combination forms imines, ligands that, when interacting with a metal of transition, generates the complexes of Salicilimina, for the particular case they will be made with nickel (II)

The synthesis designed between aldehyde and amine, will generate the formation of imine, which in the second reaction stage, as a product we will obtain the complexes of Saliciliminas, nickel (II), said synthesis is carried out following a specific methodology, under established conditions and with microwave assistance, which gives importance to the synthesis of Nickel catalytic complexes, since it shortens the reaction time of the catalysis, allows product purity, avoids higher costs and generates less waste that pollutes the environment. Thermogravimetric analysis is carried out to corroborate the initial and final decomposition temperature for each of the samples, to agree on the results and to be able to reproduce more research studies. The synthesis of the complexes of nickel Salicillimines (II), reaction using the one pot method, combined with the use of microwaves, allows reducing reaction stages, time and costs. These complexes will be used for future reactions with the interest of the research group in projects already designed, of Suzuki-Miyaura couplings, this type of complex is applied for photocatalysis, industry and biological activity. Such is the case of the process of obtaining valsartan, an aid in the treatment of hypertension. Due to the above, the synthesis of nickel-derived catalysts is proposed, which effectively catalyze the generation of biphenyl skeletons, in processes with lower cost, as a consequence of the use of a more abundant and cheaper metal