Reactividad de nitrocetonas frente a dihidrofuranos

Abstract

The development of new compounds with biological value has oriented the chemical synthesis to develop "Blocking Blocks" that allow to simulate the properties of natural products, and more if they appear enatiomerically pure. Therefore, the present investigation is oriented to the development of a new substance based on the reactivity of benzoylnitromethane, in Michael reactions and in turn, in recognizing the reactivity of 2,5-dihydrofuran when exposed to conjugate additions. Firstly, the methodology is oriented in the identification of the ideal conditions that contribute to the formation of the product, quantifying time, concentration and of course the adequate solvent, it was possible to identify correctly the minimum conditions to obtain the product without forgetting the appropriate catalyst, additionally we have resorted to 1H-NMR spectroscopy , two-dimensional COSY and HSQC in the characterization; in this way, the structure of the product of the reaction, according to the reaction mechanisms present in the Michael additions is proposed, however, the product obtained was not obtained enantiomerically pure.