Determinación de los polimorfismos (rs1815739) y (rs1799752) en los Genes ACTN3 y ACE en una muestra de atletas colombianos de rendimiento (n 37) y un grupo control (n 37)

Abstract

There are genetic sequences that could be associated with better athletic performance, such as the I/D polymorphisms in the ACE gene and R577X in the ACTN3 gene, which are related to phenotypes of greater muscular strength and endurance. The purpose of this work was to initiate an exploratory study in two polymorphisms, ACE (rs1799752) and ACTN3 (rs1815739) to determine their presence and assess whether there is an association with anthropometric and performance variables according to sport specificity / specialty in 37athletes of background and strength-speed of Coldeportes. Whole blood was taken for extraction, quantification and amplification of cDNA by conventional PCR to genotyping athletes and controls. A moderate association was found between the ACE gene polymorphism and the force-speed, resistance and control group; however, the polymorphism of the ACTN3 gene did not have a significant association. The results of this study could contribute to the molecular characterization of athletes and optimize methodologies to identify sports talents at an early age.