Modelo de colisiones entre nanopartículas magnéticas y la pared arterial

Abstract

Cancer, a highly prevalent pathology both in Colombia and worldwide, has spurred research focused on less invasive treatments than conventional chemotherapy. This study centers on an emerging alternative: Magnetic Drug Targeting (MTD) through magnetic nanoparticles on the arterial wall.

A simulation model in C++ based on the Kinetic Monte Carlo method was developed to study processes such as adsorption, absorption, and desorption of these nanoparticles. Essential variables include the thickness of endothelial cells in the arterial wall, ranging from 0.1 to 1 μm, and characteristics of nanoparticles such as a diameter of 200 nm, a speed of 0.5 m/s, and a density of 6450 kg/m3.

The model is evaluated in four phases, adjusting the pore size and activation energy in the arterial wall. The results suggest that both pore size and nanoparticle radius are crucial for effective drug delivery. This study not only contributes to the optimization of the MTD technique but also identifies key areas that require further research.