Modelado de la cinética de nanopartículas en el torrente sanguíneo bajo la influencia de un campo magnético externo.

Abstract

Magnetic drug targeting is a non-invasive biomedical technique for localized diseases treatment. This technique is based on the binding of the drug to the surface of nanoparticles with a magnetizable core, suspended in a liquid known as a ferrofluid, which is injected into the bloodstream and directed to the target region through external magnetic fields. In the present document, the kinetic behavior of a magnetic nanoparticle initially subjected to external magnetic fields is compared and, then four moments of the cardiac cycle are added to understand the dynamic effect due to blood pulsation. A blood vessel without bifurcations and radial symmetry of 100 micrometers in diameter with the pulsating flow and a magnetic nanoparticle of 100 nm radius, directed by external magnetic fields associated with a cylindrical neodymium magnet, is approached. Two forces are taken into account: the magnetic force on the nanoparticle and the drag force influenced by the velocity profiles of the blood flow, as well as the velocity of the same. The results show that the nanoparticles that fall under the influence of the magnetic field alter their trajectory by modifying the distance between the magnet and the center of the blood vessel, as well as the moment of the cardiac cycle in which the system is found.