El cáncer : una mirada biofísica a través de la membrana celular

Abstract

The cell membrane is mainly composed of a lipid bilayer, which ultimately determines its biophysical properties, since lipids are important elements that regulate several cellular functions, i.e., they serve to protect the cell and regulate the traffic of substances inside and outside it. This regulation is carried out through a complex system of processes that occur through interactions of the membrane components with their surrounding environment, from the molecular point of view, some of the main theories, currently accepted about cancer, indicate that it starts due to the accumulation of alterations in essential genes in the control of cell proliferation and cell death. Cancer affects the cell membrane and these properties are altered, resulting in an imbalance in its initial structure. The fundamental purpose of this work is to study the implications on the cell membrane due to the fundamental purpose of this work is to study the implications on the cell membrane due to the affectations that cancer generates at the cellular level according to these theories with the help of molecular dynamics methods. For this purpose, a computational simulation will be implemented in the Gromacs suite, where we will focus essentially on the characterization of the biomechanics of the membrane due to the changes that are generated in the cell caused by cancer.