Síntesis y Reactividad de Bencilaminas frente a Acido Oxálico Activado

Abstract

Benzylamines are organic compounds with important industrial applications, among they highlight the synthesis of enzymatic inhibitors, their use as analgesics, antibacterials and fungicides, and be intermediaries in the amination of compounds heterocyclic The benzylamines were extracted by means of reductive aminations of aromatic aldehydes. In a previous study, it was established that 3,4-dimethoxybenzylamine it reacts in a regioselective way against an oxidic oxidized with dicyclohexylcarbodiimide by means of an aromatic electrophilic substitution, giving as product 6,7-dimethoxy-1,2-dihydroisoquinoline-3,4-dione, heterocyclic compound of important biological interest due to its high pharmacological activity. Other studies report the influence of hydroxyl groups present on the aromatic ring phenylethylamines in the solution against non-enolizable aldehydes, establishing that the degree of hydroxylation present on the aromatic ring generates differences differences in the products obtained In the present work the synthesis by reductive amination of 1- (naphthalen-1-yl) methanamine and 1- (4-methoxyphenyl) methanamine from 1-Naphtaldehyde and 4-anisaldehyde respectively and their behavior against an oxidic oxidized with dicyclohexylcarbodiimide (DCC). It was established that both benzylamines and alcohols benzyl with activated rings product benzofused linear and cyclic products of 6 members.