Estudio del transporte de Piridin Nucleotidos en Leishmania Braziliensis: Producción y caracterización de un anticuerpo (IgYs), antitransportador del NAD+ LbTNTA
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Leishmaniasis is a disease caused by Leishmania, an intracellular protozoan parasite transmitted by the female mosquito, which infects both humans and animals. This disease manifests itself cutaneously, mucocutaneously and viscerally. This disease is found in tropical and subtropical areas such as case of Colombia that tops the list of countries with 9 species of this parasite [39] of the 20 identified, being Leishmaniasis braziliensis (Cutaneous disease) the most frequent with 98% incidence between 20,000 to 30,000 of the cases reported while the form mucosa and visceral is given by 2% [38]. The action against this disease has occurred through drugs that generate various adverse side effects to the individual [29], generating the interest of study to find possible therapeutic targets that can identify and treat the disease. In the group, Basic Research Laboratory in Biochemistry (LIBBIQ) of the National University of Colombia, research has been carried out on the biological study of the parasite, characterizing it in a molecular and biochemical way, identifying the cloning of the NMNAT of Leishmania as an enzyme that intervenes in the synthesis of the NAD and establishing candidate proteins to transport this di-nucleotide.