Potential application of ivim and dwi imaging in parkinson’s disease
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Universidad Distrital Francisco José de Caldas. Colombia
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Parkinson’s disease (PD) is a progressive degenerative neurological condition, which origin remains unclear. We are interested in proposing the study ofblood flow in the substantia nigra (SN) in PD patients, based on findings that demonstrated relative hypoactivity in PD patients located to subthalamicnucleus and SN. It is believed that this hipoactivity may suggest changes in the blood flow to the SN, where the particular loss of dopaminergic neuronsoccurs.The method used is the Incoherent Motion Intravoxel (IVIM) that allows measurement of blood flow to the microvascular level and recently has been producing high resolution quantitative perfusion maps.This paper proposes to measure the perfusion in PD patients and find any correlation with neural activity and water displacements within thetissue. Assuming decreasing the local perfusion suggests the possible impairments that affect the neural activity in PD causing the progressivedeath of neurons in the SN.
Parkinson’s disease (PD) is a progressive degenerative neurological condition, which origin remains unclear. We are interested in proposing the study ofblood flow in the substantia nigra (SN) in PD patients, based on findings that demonstrated relative hypoactivity in PD patients located to subthalamicnucleus and SN. It is believed that this hipoactivity may suggest changes in the blood flow to the SN, where the particular loss of dopaminergic neuronsoccurs.The method used is the Incoherent Motion Intravoxel (IVIM) that allows measurement of blood flow to the microvascular level and recently has been producing high resolution quantitative perfusion maps.This paper proposes to measure the perfusion in PD patients and find any correlation with neural activity and water displacements within thetissue. Assuming decreasing the local perfusion suggests the possible impairments that affect the neural activity in PD causing the progressivedeath of neurons in the SN.
Parkinson’s disease (PD) is a progressive degenerative neurological condition, which origin remains unclear. We are interested in proposing the study ofblood flow in the substantia nigra (SN) in PD patients, based on findings that demonstrated relative hypoactivity in PD patients located to subthalamicnucleus and SN. It is believed that this hipoactivity may suggest changes in the blood flow to the SN, where the particular loss of dopaminergic neuronsoccurs.The method used is the Incoherent Motion Intravoxel (IVIM) that allows measurement of blood flow to the microvascular level and recently has been producing high resolution quantitative perfusion maps.This paper proposes to measure the perfusion in PD patients and find any correlation with neural activity and water displacements within thetissue. Assuming decreasing the local perfusion suggests the possible impairments that affect the neural activity in PD causing the progressivedeath of neurons in the SN.
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Parkinson's disease (PD), Intravoxel incoherent motion (IVIM), Diffusion Weighted Imaging (DWI), Substantia nigra (SN)., Diffusion Weighted Imaging (DWI), Intravoxel incoherent motion (IVIM), Parkinson’s disease (PD), Substantia nigra (SN).