Estudio morfométrico comparativo de la capa granular externa en cerebelos humanos durante el desarrollo fetal entre las semanas 10 y 32 de gestación en humanos con exposición a hipoxia y sin compromiso hipóxico crónico

Abstract

Fetal hypoxia, understood as oxygen deficiency during pregnancy, is of great medical interest as it is one of the main causes of pregnancy complications and generates alterations in the central nervous system (CNS). In the cerebellum, it can lead to complications that result in cognitive, behavioral, and language impairments. In this study, a morphometric analysis was carried out on 22 samples of human fetal cerebella of different gestational ages, with the aim of evaluating the effect of hypoxia on the thickness of the external granular layer and Purkinje cells, based on histological sections stained with hematoxylin-eosin. A MANOVA statistical analysis was applied using Python and PAST5, resulting in no significant difference in the variation of the external granular layer thickness between fetuses with hypoxia and those without hypoxic exposure, although it could alter the cellular maturation of this layer, which opens the opportunity for further in vivo studies.